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Alaoui Lab

Discovering Novel Ways to Improve Early Detection and Treatments for Thoracic Malignancies

The Alaoui Lab is a core component of the UCSF Thoracic Oncology Lab. Lung cancer is the leading cause of cancer death worldwide and early detection is critcal to its treatment. The Alaoui lab seeks to identify and characterize the molecular pathways critical to the development of lung cancer and to find methods for targeting them, most notably the role of the epidermal growth factor receptor (EGFR) in lung carcinogenesis and reactivation of embryonic signaling pathways such as Wnt signaling. It is also investigating two extracellular regulators of Wnt signaling, Sulf-1 and Sulf-2, as new therapeutic targets. The lab utilizes state-of-the-art molecular and cellular technogies for conducting research including the Affy-gene Titan high throughput expression analysis and ABI HT 7900 qPCR and have access to the  Thoracic Oncology Tissue Bank, one of the world's largest repositories of lung tumor tissue specimens.

Recent Publications

Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C
TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells.
PloS one, [epublish] 63: e17489.
Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C
TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells.
PloS one, [epublish] 63: e17489.
Rosen SD, Lemjabbar-Alaoui H
Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate.
Expert opinion on therapeutic targets, Sep-01-2010; 149: 935-49.
Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C
EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis.
Oncogene, Jul-22-2010; 2929: 4145-56.  Epub 2010 May 31.
Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD
Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis.
Oncogene, Feb-04-2010; 295: 635-46.  Epub 2009 Oct 26.
Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD
Use of a phage display antibody to measure the enzymatic activity of the Sulfs.
Methods in enzymology, 480: 51-64.
Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N
Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"?.
American journal of respiratory cell and molecular biology, Jul-01-2006; 351: 3-9.  Epub 2006 Feb 16.
Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C
Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer.
PloS one, [epublish] 1: e93.
Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C
Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.
The Journal of biological chemistry, Sep-10-2004; 27937: 39085-93.
Londhe V, McNamara N, Lemjabbar H, Basbaum C
Viral dsRNA activates mucin transcription in airway epithelial cells.
FEBS letters, Oct-09-2003; 5531-2: 33-8.
Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C
Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin.
The Journal of biological chemistry, Jul-11-2003; 27828: 26202-7.
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