Alaoui Lab »  People »  Alumni »  Petra C. Buchanan, Ph.D.
Petra C. Buchanan, Ph.D.

Petra C. Buchanan, Ph.D.

Postdoctoral Fellow

Contact Information

2340 Sutter St, Room N231
San Francisco, CA 94143-1724
(415) 502-0555
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  • Friedrich-Alexander-University, Erlangen-Nuernberg, Germany Diplom, Biology (equivalent to M.S.), 2009
  • Friedrich-Alexander-University, Erlangen-Nuernberg, Germany Dr. rer. nat. in Biology (equivalent to Ph.D.), 2011
  • Cancer Immunobiology
  • Danger signals
  • Dendritic cells
  • Hyperthermia in multimodal cancer therapies
  • Immunogenic cell death
  • Novel biomarkers for the early detection of lung cancer

Petra joined the lab in 2012 as a postdoctoral researcher and Assistant Specialist. Prior to joining the Alaoui lab at UCSF, she earned her Ph.D. (Dr. rer. nat.) in 2011 and her M.S. (Dipl. Biol.) in 2009, both from the Friedrich-Alexander-University in Germany. Her dissertation investigated the immunogenic potential of colorectal tumor cells after treatment with X-radiation and hyperthermia. It showed that the combined treatment induces an immune activating tumor microenvironment, through increased amounts of immunogenic necrotic cell death, the release of danger signals, and the activation of dendritic cells in an HSP70-dependent manner.

Dr. Buchanan's research focus is the investigation of novel biomarkers for the early detection of lung cancer, including the quantification and characterization of extracellular sulfatases (SULFs), their heparan sulfate proteoglycan substrates, and heparin-binding factors in NSCLC patients.

1. P. Schildkopf, B. Frey, O.J. Ott, Y. Rubner, G. Multhoff, R. Sauer, R. Fietkau, U.S. Gaipl. ?Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages,? Radiother Oncol. Oct 2011; 101(1): 109-15.
2. P. Schildkopf, O.J. Ott, B. Frey, M. Wadepohl, R. Sauer, R. Fietkau, U.S. Gaipl. ?Biological Rationales and Clinical Applications of Temperature Controlled Hyperthermia?Implications for Multimodal Cancer Treatments,? Curr Med Chem. 2010; 17(27): 3045-57.
3. P. Schildkopf, B. Frey, F. Mantel, O.J. Ott, E.M. Weiss, R. Sieber, C. Janko, R. Sauer, R. Fietkau, and U.S. Gaipl. ?Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells,? Biochem Biophys Res Commun. Jan 2010; 391(1): 1014-20.
4. B. Frey, P. Schildkopf, F. R?del, E.M. Weiss, L.E. Munoz, M. Herrmann, R. Fietkau, and U.S. Gaipl. ?AnnexinA5 renders dead tumor cells immunogenic?implications for multimodal cancer therapies,?J Immunotoxicol. Dec 2009; 6(4): 209-16.
5. P. Schildkopf, R. Holmer, R. Sieber, O.J. Ott, C. Janko, F. Mantel, B. Frey, R. Fietkau, and U.S. Gaipl. ?Hyperthermia in combination with X-irradiation induces inflammatory forms of cell death,? Autoimmunity. May 2009; 42(4): 311-3.

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