Alaoui Lab »  Collaborators »  Collaborators »  Steven D. Rosen, Ph.D.
Steven D. Rosen, Ph.D.

Steven D. Rosen, Ph.D.

Professor and Vice-Chair, Department of Anatomy, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS)
Member, UCSF Herbert W. Boyer Program in Biological Sciences (PIBS)
Member, UCSF Immunology Graduate Program

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We are investigating molecular mechanisms underlying the adhesion of blood-borne lymphocytes to the specialized endothelial cells of lymph node high endothelial venules (HEV). Our early studies suggested that a surface glycoprotein (gp90MEL) on mouse lymphocyte, functioning as a calcium-dependent lectin, mediates this interaction. In collaboration with Genentech, we cloned gp90MEL (now known as L-selectin) and demonstrated the existence of an amino terminal calcium-type lectin domain. Two other cell adhesion proteins cloned at the same time (E-selectin and P-selectin) also possess calcium-type lectin domains. These three proteins, now termed selectins, define a new family of cell adhesion proteins which all function as cell surface lectins in a wide variety of leukocyte-endothelial interactions.